The Western Health Nephrology Department has clinicians, nurses, pharmacists and allied health staff actively involved in research to help better understand kidney diseases and to improve outcomes for patients with kidney diseases.

The department is led by Associate Professor Craig Nelson and collaborates strongly with research groups such as the Australian Kidney Trials Network and the Victorian Renal Clinical Network to actively lead research as well as participate in a broad range of national and international clinical trials (investigator and sponsored trials).

Current active research includes:

AKTN IMPROVE: A randomized, double-blind, placebo-controlled trial to assess the effect of phosphate reduction with lanthanum carbonate on arterial compliance and vascular calcification in patients with chronic kidney disease stages 3-4.

AKTN CKD-FIX:  Controlled trial of slowing of Kidney Disease progression From the Inhibition of Xanthine oxidase

REMOVAL HD: A tRial Evaluating Mid cut-Off Value membrane clearance of Albumin and Light chains in HaemoDialysis patients

REDUCCTION: Reducing the burden of dialysis Catheter Complications: a National approach (He REDUCCTION partnership project

ASCEND Trials: Phase III, investigating efficacy of Daprodustat (hypoxia-inducible factor prolyl-hydroxylase inhibitor) (HIF-PHI) in anaemia associated with CKD.

FIGARO/FIDELIO: Efficacy and safety of finerenone in subjects with type 2 diabetes mellitus and the clinical diagnosis of diabetic kidney disease

PODOCYTE: Phase II investigating efficacy on and safety of Corticotropin in the Treatment of Proteinuria due to Treatment Resistant/Treatment Intolerant Primary FSGS.

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Safety and Efficacy of CCX168 (Avacopan) in Patients with Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis Treated Concomitantly with Rituximab or Cyclophosphamide/Azathioprine.

Chronic Disease IMPACT:  Chronic Disease IMPACT (Chronic Disease early detection and Improved Management in PrimAry Care ProjecT).